When I first got the bike I used Road to get used to the power & torque, then once I was happy enough riding in that I thought I'd give Sport a try, that's where the Penner Tune resides, there & also Custom. A noticeable difference in acceleration, throttle response was evident using Sport, so switched back to Road. Couple of days later thought I'd give Sport another go, I mean, it's there & awesome, so why not use it? Changed to Sport & left it there, another learning curve but all went well.
I changed back to Road to give it a try after a good while using Sport & the bike felt, well not 'dead' but definitely lacking the crisp throttle response I'd got used to. I now much prefer to ride in Sport mode all the time, it just makes the bike come alive. In rain I do switch to Rain mode though, I do like the power but I don't have a death wish.
Custom mode is set similar to Sport, but with T/C turned off, don't think I'm ready for that yet & am happy with Sport setup. I know I can modify the mode setups, but I'm ok with them as I've got them - for now.
So, in answer to the OP's question, I use "Penner Sport" mode 99% of the time.