Flat tires are always a possibility, I've had 2 and was lucky in both cases,one was in my garage, other in Canada getting off of the ferry from Nova Scotia, got to a garage and a real friendly guy just stopped what he was doing and helped me out.
Having said that, I'm sure that will not always be the case, so I'm thinking this through. I think the biggest issue will be rolling the bike so that the problem can be found or moved so that it can be worked upon. Most punctures are slow and the air pressure loss can be felt sooner or later, but can be observed immediately if one has TPS on the tires. (several options here, stand alone 2 tire TPS, or a GPS unit with TPS monitoring capability) So if one sees the pressure decreasing, it's time to investigate, bike can be easily rolled
to find the issue. Plugging is easily done, then insert air by your chosen means.
I think this avoids having the tire loosen the bead and makes it a lot easier to deal with before the worst happens.
Anyways just wanted to share my thoughts on air leaks and how it can be not such a big deal.
Hoopla