Everything is relative. If you have power mods and regularly "abuse" the power then you can expect your drive will fail faster. Most people though aren't constantly on the adrenaline even with major upgrades so I would not expect much longevity issues from the drivetrain or transmission.
Clutch though is a different story. Stock clutches seem pretty weak and even the Barnett Performance clutch is a tad insufficient, well, maybe... I'm thinking the Rocket clutch system needs a better design, but that's a different story.
The "drivetrain" issues (torsional bearing failure) that people have reported occur on bone stock machines as well as heavily modified ones and seem most related to mileage done - around 10000 to 14000 miles, so far as upgrades and drivetrain issues, there is no correlation.